The method, implemented as a Max audio device for use in a digital audio workstation (DAW), provides unparalleled insights into the rich vibrational signatures of protein structures, and offers a new way for creative expression by using it as a new type of musical instrument. We then use the resulting frequency spectra of the proteins to generate audible sound by overlaying the molecular vibrations and translating them to the audible frequency range using the music theoretic concept of transpositional equivalence. Using this new algorithm we report a comprehensive database of the normal mode frequencies of all known protein structures, which has not been available before. We report a high-throughput method that enables us to automatically compute the vibrational spectra of more than 100,000 proteins available in the Protein Data Bank to date, in a consistent manner.
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11/26/2023 09:12:06 pm
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